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The peptide has gained popularity among athletes and the general public for injury recovery, leading the World Anti-Doping Agency to ban it in 2022

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For instance, in different cancer entities that harbor a mutation in either the isocitrate dehydrogenase (NADP (+1)) ( IDH1 ) or NADP(+2) ( IDH2 ) locus, the first oncometabolite (D)-2-hydroxygluterate (D-2HG) was identified