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That is because the administration of ascorbate into a high oxidative stress environment increases tissue concentrations of glutathione, indicating that ascorbate (vitamin C) spares glutathione

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In gynecologic oncology, particularly in cervical and endometrial cancers, curcumin may be integrated into combination regimens with chemotherapy, radiotherapy, or hormonal therapies to potentiate treatment responses, mitigate therapy-induced inflammation, and potentially overcome drug resistance through modulation of key signaling pathways such as NF-κB, STAT3, and PI3K/Akt