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As noted above, Trxs are responsible for reducing Prx back to their reduced, oxidant-scavenging state, while thioredoxin reductases (TrxRDs) keep the reduced state of Trxs using NAPDH reducing equivalents, as depicted in Figure 2

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In vitro experiments evidenced that GPx was enhanced in steatotic immortalized human hepatocytes [102]

Carnitine is a naturally occurring amino acid derivative that plays a crucial role in energy production by transporting fatty acids into the mitochondria